Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

Polycythemia is often associated with erythropoietin (EPO) overexpression and defective oxygen sensing. In normal cells, intracellular oxygen concentrations are directly sensed by prolyl hydroxylase domain (PHD)–containing proteins, which tag hypoxia-inducible factor (HIF) α subunits for polyubiquit...

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Autors principals: Takeda, Kotaro, Aguila, Hector L., Parikh, Nehal S., Li, Xiping, Lamothe, Katie, Duan, Li-Juan, Takeda, Hiromi, Lee, Frank S., Fong, Guo-Hua
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Red Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265459/
https://ncbi.nlm.nih.gov/pubmed/18056838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-114561
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