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Integrity of the Prolyl Hydroxylase Domain Protein 2:Erythropoietin pathway in aging mice
The central transcriptional response to hypoxia is mediated by the Prolyl Hydroxylase Domain protein (PHD):Hypoxia Inducible Factor (HIF) pathway. In this pathway, PHD prolyl hydroxylates and thereby negatively regulates the α-subunit of the transcription factor HIF (HIF-α). An important HIF target...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878925/ https://ncbi.nlm.nih.gov/pubmed/20400342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2010.03.003 |
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