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Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
The hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (PHDs) regulate the stability of HIF protein by post-translational hydroxylation of two conserved prolyl residues in its α subunit in an oxygen-dependent manner. Trans-4-prolyl hydroxylation of HIFα under normal oxygen (O(2)) avail...
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| Veröffentlicht in: | Hypoxia (Auckl) |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5045062/ https://ncbi.nlm.nih.gov/pubmed/27774472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/HP.S47968 |
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