Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism

The hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (PHDs) regulate the stability of HIF protein by post-translational hydroxylation of two conserved prolyl residues in its α subunit in an oxygen-dependent manner. Trans-4-prolyl hydroxylation of HIFα under normal oxygen (O(2)) avail...

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Bibliografiske detaljer
Udgivet i:Hypoxia (Auckl)
Main Authors: Yang, Ming, Su, Huizhong, Soga, Tomoyoshi, Kranc, Kamil R, Pollard, Patrick J
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2014
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045062/
https://ncbi.nlm.nih.gov/pubmed/27774472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/HP.S47968
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