Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges

Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged i...

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Detalles Bibliográficos
Publicado en:Hypoxia (Auckl)
Main Authors: Harnoss, Jonathan Michael, Strowitzki, Moritz Johannes, Radhakrishnan, Praveen, Platzer, Lisa Katharina, Harnoss, Julian Camill, Hank, Thomas, Cai, Jun, Ulrich, Alexis, Schneider, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2015
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045068/
https://ncbi.nlm.nih.gov/pubmed/27774478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/HP.S60872
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