Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-inducible factor (HIF) pathway. The HIF pathway is c...

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Publicado en:JCI Insight
Main Authors: Strowitzki, Moritz J., Kimmer, Gwendolyn, Wehrmann, Julian, Ritter, Alina S., Radhakrishnan, Praveen, Opitz, Vanessa M., Tuffs, Christopher, Biller, Marvin, Kugler, Julia, Keppler, Ulrich, Harnoss, Jonathan M., Klose, Johannes, Schmidt, Thomas, Blanco, Alfonso, Taylor, Cormac T., Schneider, Martin
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119215/
https://ncbi.nlm.nih.gov/pubmed/33784253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139191
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