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Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

All metazoans that utilize molecular oxygen (O(2)) for metabolic purposes have the capacity to adapt to hypoxia, the condition that arises when O(2) demand exceeds supply. This is mediated through activation of the hypoxia-inducible factor (HIF) pathway. At physiological oxygen levels (normoxia), HI...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cells
Hauptverfasser: Strowitzki, Moritz J., Cummins, Eoin P., Taylor, Cormac T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562979/
https://ncbi.nlm.nih.gov/pubmed/31035491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8050384
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