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Crystal structures of Leishmania mexicana arginase complexed with α,α-disubstituted boronic amino-acid inhibitors

Leishmania arginase is a potential drug target for the treatment of leishmaniasis because this binuclear manganese metalloenzyme initiates de novo polyamine biosynthesis by catalyzing the hydrolysis of l-arginine to generate l-ornithine and urea. The product l-ornithine subsequently undergoes decarb...

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Bibliografiske detaljer
Udgivet i:Acta Crystallogr F Struct Biol Commun
Main Authors: Hai, Yang, Christianson, David W.
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822987/
https://ncbi.nlm.nih.gov/pubmed/27050264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16003630
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