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Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design()
Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutical...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150614/ https://ncbi.nlm.nih.gov/pubmed/21728378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200443b |
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