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Crystal structures of Leishmania mexicana arginase complexed with α,α-disubstituted boronic amino-acid inhibitors
Leishmania arginase is a potential drug target for the treatment of leishmaniasis because this binuclear manganese metalloenzyme initiates de novo polyamine biosynthesis by catalyzing the hydrolysis of l-arginine to generate l-ornithine and urea. The product l-ornithine subsequently undergoes decarb...
Guardat en:
| Publicat a: | Acta Crystallogr F Struct Biol Commun |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
International Union of Crystallography
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822987/ https://ncbi.nlm.nih.gov/pubmed/27050264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16003630 |
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