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2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I

Arginase, a key metalloenzyme of the urea cycle that converts L-arginine into L-ornithine and urea, is presently considered a pharmaceutical target for the management of diseases associated with aberrant L-arginine homeostasis, such as asthma, cardiovascular diseases, and erectile dysfunction. We no...

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Hlavní autoři: Ilies, Monica, Di Costanzo, Luigi, North, Michelle L., Scott, Jeremy A., Christianson, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874077/
https://ncbi.nlm.nih.gov/pubmed/20441173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100306a
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