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Probing the Specificity Determinants of Amino Acid Recognition by Arginase,
Arginase is a binuclear manganese metalloenzyme that serves as a therapeutic target for the treatment of asthma, erectile dysfunction, and atherosclerosis. In order to better understand the molecular basis of inhibitor affinity, we have employed site-directed mutagenesis, enzyme kinetics, and X-ray...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665027/ https://ncbi.nlm.nih.gov/pubmed/19093830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801911v |
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