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Probing the Specificity Determinants of Amino Acid Recognition by Arginase,

Arginase is a binuclear manganese metalloenzyme that serves as a therapeutic target for the treatment of asthma, erectile dysfunction, and atherosclerosis. In order to better understand the molecular basis of inhibitor affinity, we have employed site-directed mutagenesis, enzyme kinetics, and X-ray...

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Detalhes bibliográficos
Main Authors: Shishova, Ekaterina Y., Di Costanzo, Luigi, Emig, Francis A., Ash, David E., Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665027/
https://ncbi.nlm.nih.gov/pubmed/19093830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801911v
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