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Probing the Specificity Determinants of Amino Acid Recognition by Arginase,
Arginase is a binuclear manganese metalloenzyme that serves as a therapeutic target for the treatment of asthma, erectile dysfunction, and atherosclerosis. In order to better understand the molecular basis of inhibitor affinity, we have employed site-directed mutagenesis, enzyme kinetics, and X-ray...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665027/ https://ncbi.nlm.nih.gov/pubmed/19093830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801911v |
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