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Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.

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Autors principals: Zakharian, Tatiana Y., Di Costanzo, Luigi, Christianson, David W.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790808/
https://ncbi.nlm.nih.gov/pubmed/18802628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b811797g
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