Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes

[Image: see text] Isocitrate dehydrogenase is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG). To investigate the early events following acquisition of this mutation in mammalian cells we crea...

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Publicat a:J Am Chem Soc
Autors principals: Walker, Olivia S., Elsässer, Simon J., Mahesh, Mohan, Bachman, Martin, Balasubramanian, Shankar, Chin, Jason W.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821487/
https://ncbi.nlm.nih.gov/pubmed/26761588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07627
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