ロード中...
Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
[Image: see text] Isocitrate dehydrogenase is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG). To investigate the early events following acquisition of this mutation in mammalian cells we crea...
保存先:
| 出版年: | J Am Chem Soc |
|---|---|
| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2016
|
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4821487/ https://ncbi.nlm.nih.gov/pubmed/26761588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07627 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|