The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

BACKGROUND & AIMS: Patients with cholestatic disease have increased systemic concentrations of bile acids (BAs) and profound pruritus. The G-protein–coupled BA receptor 1 TGR5 (encoded by GPBAR1) is expressed by primary sensory neurons; its activation induces neuronal hyperexcitability and scrat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Gastroenterology
Prif Awduron: Lieu, TinaMarie, Jayaweera, Gihan, Zhao, Peishen, Poole, Daniel P., Jensen, Dane, Grace, Megan, McIntyre, Peter, Bron, Romke, Wilson, Yvette M., Krappitz, Matteus, Haerteis, Silke, Korbmacher, Christoph, Steinhoff, Martin S., Nassini, Romina, Materazzi, Serena, Geppetti, Pierangelo, Corvera, Carlos U., Bunnett, Nigel W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821165/
https://ncbi.nlm.nih.gov/pubmed/25194674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.042
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