The TGR5 receptor mediates bile acid–induced itch and analgesia

Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which are elevated in the circulation and tissues during cholestasis, cause itch and analgesia by activating the GPCR TGR5. TGR5 was detected in pept...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Alemi, Farzad, Kwon, Edwin, Poole, Daniel P., Lieu, TinaMarie, Lyo, Victoria, Cattaruzza, Fiore, Cevikbas, Ferda, Steinhoff, Martin, Nassini, Romina, Materazzi, Serena, Guerrero-Alba, Raquel, Valdez-Morales, Eduardo, Cottrell, Graeme S., Schoonjans, Kristina, Geppetti, Pierangelo, Vanner, Stephen J., Bunnett, Nigel W., Corvera, Carlos U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613908/
https://ncbi.nlm.nih.gov/pubmed/23524965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64551
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados