The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

BACKGROUND & AIMS: Patients with cholestatic disease have increased systemic concentrations of bile acids (BAs) and profound pruritus. The G-protein–coupled BA receptor 1 TGR5 (encoded by GPBAR1) is expressed by primary sensory neurons; its activation induces neuronal hyperexcitability and scrat...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Gastroenterology
Главные авторы: Lieu, TinaMarie, Jayaweera, Gihan, Zhao, Peishen, Poole, Daniel P., Jensen, Dane, Grace, Megan, McIntyre, Peter, Bron, Romke, Wilson, Yvette M., Krappitz, Matteus, Haerteis, Silke, Korbmacher, Christoph, Steinhoff, Martin S., Nassini, Romina, Materazzi, Serena, Geppetti, Pierangelo, Corvera, Carlos U., Bunnett, Nigel W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821165/
https://ncbi.nlm.nih.gov/pubmed/25194674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.042
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы