The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

BACKGROUND & AIMS: Patients with cholestatic disease have increased systemic concentrations of bile acids (BAs) and profound pruritus. The G-protein–coupled BA receptor 1 TGR5 (encoded by GPBAR1) is expressed by primary sensory neurons; its activation induces neuronal hyperexcitability and scrat...

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Foilsithe in:Gastroenterology
Main Authors: Lieu, TinaMarie, Jayaweera, Gihan, Zhao, Peishen, Poole, Daniel P., Jensen, Dane, Grace, Megan, McIntyre, Peter, Bron, Romke, Wilson, Yvette M., Krappitz, Matteus, Haerteis, Silke, Korbmacher, Christoph, Steinhoff, Martin S., Nassini, Romina, Materazzi, Serena, Geppetti, Pierangelo, Corvera, Carlos U., Bunnett, Nigel W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821165/
https://ncbi.nlm.nih.gov/pubmed/25194674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.042
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