Allosteric signaling through an mGlu2 and 5-HT(2A) heteromeric receptor complex and its potential contribution to schizophrenia

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the pharmacology and functions of the constituent receptors. Previous findings demonstrated that the G(q/11)-coupled serotonin 5-HT(2A) receptor and t...

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Publicado no:Sci Signal
Main Authors: Moreno, José L., Miranda-Azpiazu, Patricia, García-Bea, Aintzane, Younkin, Jason, Cui, Meng, Kozlenkov, Alexey, Ben-Ezra, Ariel, Voloudakis, Georgios, Fakira, Amanda K., Baki, Lia, Ge, Yongchao, Georgakopoulos, Anastasios, Morón, José A., Milligan, Graeme, López-Giménez, Juan F., Robakis, Nikolaos K., Logothetis, Diomedes E., Meana, J. Javier, González-Maeso, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819166/
https://ncbi.nlm.nih.gov/pubmed/26758213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab0467
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