Repressive Epigenetic Changes at the mGlu2 Promoter in Frontal Cortex of 5-HT(2A) Knockout Mice

Serotonin 5-HT(2A) and metabotropic glutamate 2 (mGlu2) are G protein–coupled receptors suspected in the pathophysiology of psychiatric disorders, such as schizophrenia, depression, and suicide. Previous findings demonstrate that mGlu2 mRNA expression is down-regulated in brain cortical regions of 5...

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Main Authors: Kurita, Mitsumasa, Moreno, José L., Holloway, Terrell, Kozlenkov, Alexey, Mocci, Giuseppe, García-Bea, Aintzane, Hanks, James B., Neve, Rachael, Nestler, Eric J., Russo, Scott J., González-Maeso, Javier
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657099/
https://ncbi.nlm.nih.gov/pubmed/23508685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084582
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