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HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Histone deacetylases (HDACs) compact chromatin structure and repress gene transcription. In schizophrenia, clinical studies demonstrate that HDAC inhibitors are efficacious when given in combination with atypical antipsychotics. However, the molecular mechanism that integrates a better response to a...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431440/ https://ncbi.nlm.nih.gov/pubmed/22864611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3181 |
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