HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

Histone deacetylases (HDACs) compact chromatin structure and repress gene transcription. In schizophrenia, clinical studies demonstrate that HDAC inhibitors are efficacious when given in combination with atypical antipsychotics. However, the molecular mechanism that integrates a better response to a...

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Main Authors: Kurita, Mitsumasa, Holloway, Terrell, García-Bea, Aintzane, Kozlenkov, Alexey, Friedman, Allyson K., Moreno, José L., Heshmati, Mitra, Golden, Sam A., Kennedy, Pamela J., Takahashi, Nagahide, Dietz, David M., Mocci, Giuseppe, Gabilondo, Ane M., Hanks, James, Umali, Adrienne, Callado, Luis F., Gallitano, Amelia L., Neve, Rachael L., Shen, Li, Buxbaum, Joseph D., Han, Ming-Hu, Nestler, Eric J., Meana, J. Javier, Russo, Scott J., González-Maeso, Javier
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431440/
https://ncbi.nlm.nih.gov/pubmed/22864611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3181
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