Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta

BACKGROUND: Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, neurodegeneration, and memory impairments. To gain an insight into molecular...

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Veröffentlicht in:BMC Biol
Hauptverfasser: Kuzuya, Akira, Zoltowska, Katarzyna M., Post, Kathryn L., Arimon, Muriel, Li, Xuejing, Svirsky, Sarah, Maesako, Masato, Muzikansky, Alona, Gautam, Vivek, Kovacs, Dora, Hyman, Bradley T., Berezovska, Oksana
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818459/
https://ncbi.nlm.nih.gov/pubmed/27036734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0248-3
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