mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

Mammalian target of rapamycin (mTOR) is a core component of raptor-mTOR (mTORC1) and rictor-mTOR (mTORC2) complexes that control diverse cellular processes. Both mTORC1 and mTORC2 regulate several elements downstream of type I insulin-like growth factor receptor (IGF-IR) and insulin receptor (InsR)....

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Publicado no:Cell Res
Main Authors: Yin, Yancun, Hua, Hui, Li, Minjing, Liu, Shu, Kong, Qingbin, Shao, Ting, Wang, Jiao, Luo, Yuanming, Wang, Qian, Luo, Ting, Jiang, Yangfu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816127/
https://ncbi.nlm.nih.gov/pubmed/26584640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.133
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