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AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin

AMP-activated protein kinase (AMPK) is an important energy sensor that may inhibit cell proliferation or promote cell survival during stresses. Besides cyclooxygenase, AMPK is another target of the nonsteroid anti-inflammatory agent aspirin. Preclinical and clinical investigations demonstrate that a...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Gao, Mei, Kong, Qingbin, Hua, Hui, Yin, Yancun, Wang, Jiao, Luo, Ting, Jiang, Yangfu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941319/
https://ncbi.nlm.nih.gov/pubmed/26918349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7648
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