Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling

Despite the high incidence of oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI3K), PI3K inhibitors have yielded little clinical benefit for breast cancer patients. Recent epidemiological studies have suggested a therapeutic benefit from aspirin...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Henry, Whitney S., Laszewski, Tyler, Tsang, Tiffany, Beca, Francisco, Beck, Andrew H., McAllister, Sandra S., Toker, Alex
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290090/
https://ncbi.nlm.nih.gov/pubmed/27940576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2400
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