Aflatoxin B1 Up-Regulates Insulin Receptor Substrate 2 and Stimulates Hepatoma Cell Migration

Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 reportedly stimulates IGF receptor activation. Aber...

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Detalhes bibliográficos
Main Authors: Ma, Yanli, Kong, Qingbin, Hua, Hui, Luo, Ting, Jiang, Yangfu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480444/
https://ncbi.nlm.nih.gov/pubmed/23112878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047961
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