Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by translocating to the plasma membrane and inducing its rupture. The activation of MLKL occurs in a multimolecular complex (the ‘necrosome'), which is comprised of MLKL, receptor-interacting serine/threonine kinase (RIPK...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Death Differ
Hauptverfasser: Rodriguez, D A, Weinlich, R, Brown, S, Guy, C, Fitzgerald, P, Dillon, C P, Oberst, A, Quarato, G, Low, J, Cripps, J G, Chen, T, Green, D R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815980/
https://ncbi.nlm.nih.gov/pubmed/26024392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.70
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge