Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by translocating to the plasma membrane and inducing its rupture. The activation of MLKL occurs in a multimolecular complex (the ‘necrosome'), which is comprised of MLKL, receptor-interacting serine/threonine kinase (RIPK...

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Опубликовано в: :Cell Death Differ
Главные авторы: Rodriguez, D A, Weinlich, R, Brown, S, Guy, C, Fitzgerald, P, Dillon, C P, Oberst, A, Quarato, G, Low, J, Cripps, J G, Chen, T, Green, D R
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815980/
https://ncbi.nlm.nih.gov/pubmed/26024392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.70
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