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Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

TDP-43 is a DNA/RNA binding protein associated with TDP-43 proteinopathies. Many mutations have been identified in the flexible C-terminal region, which is implicated in the disease pathology. We investigated four point mutations in the amyloidogenic core region (residues 311–360) of TDP-43 by bioch...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Jiang, Lei-Lei, Zhao, Jian, Yin, Xiao-Fang, He, Wen-Tian, Yang, Hui, Che, Mei-Xia, Hu, Hong-Yu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814915/
https://ncbi.nlm.nih.gov/pubmed/27030292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23928
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