Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion

TDP-43 (TAR DNA-binding protein of 43 kDa) is a major deposited protein in amyotrophic lateral sclerosis and frontotemporal dementia with ubiquitin. A great number of genetic mutations identified in the flexible C-terminal region are associated with disease pathologies. We investigated the molecular...

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Detalhes bibliográficos
Main Authors: Jiang, Lei-Lei, Che, Mei-Xia, Zhao, Jian, Zhou, Chen-Jie, Xie, Mu-Yun, Li, Hai-Yin, He, Jian-Hua, Hu, Hong-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707662/
https://ncbi.nlm.nih.gov/pubmed/23689371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463828
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