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Interaction with Polyglutamine Aggregates Reveals a Q/N-rich Domain in TDP-43
The identification of pathologic TDP-43 aggregates in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, followed by the discovery of dominantly inherited point mutations in TDP-43 in familial ALS, have been critical insights into the mechanism of these untreatable neurodegen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924052/ https://ncbi.nlm.nih.gov/pubmed/20554523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125039 |
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