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Interaction with Polyglutamine Aggregates Reveals a Q/N-rich Domain in TDP-43

The identification of pathologic TDP-43 aggregates in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, followed by the discovery of dominantly inherited point mutations in TDP-43 in familial ALS, have been critical insights into the mechanism of these untreatable neurodegen...

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Главные авторы: Fuentealba, Rodrigo A., Udan, Maria, Bell, Shaughn, Wegorzewska, Iga, Shao, Jieya, Diamond, Marc I., Weihl, Conrad C., Baloh, Robert H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924052/
https://ncbi.nlm.nih.gov/pubmed/20554523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125039
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