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Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones

TDP-43 aggregation in the cytoplasm or nucleus is a key feature of the pathology of amyotrophic lateral sclerosis and frontotemporal dementia and is observed in numerous other neurodegenerative diseases, including Alzheimer's disease. Despite this fact, the inciting events leading to TDP-43 agg...

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Bibliografische gegevens
Hoofdauteurs: Udan-Johns, Maria, Bengoechea, Rocio, Bell, Shaughn, Shao, Jieya, Diamond, Marc I., True, Heather L., Weihl, Conrad C., Baloh, Robert H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857952/
https://ncbi.nlm.nih.gov/pubmed/23962724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt408
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