HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

The RNA-binding protein TDP-43 forms intranuclear or cytoplasmic aggregates in age-related neurodegenerative diseases. Here we show that RNA-binding deficient TDP-43 (produced by neurodegeneration-causing mutations or post-translational acetylation in its RNA recognition motifs) drove TDP-43 de-mixi...

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Udgivet i:Science
Main Authors: Yu, Haiyang, Lu, Shan, Gasior, Kelsey, Singh, Digvijay, Vazquez-Sanchez, Sonia, Tapia, Olga, Toprani, Divek, Beccari, Melinda S., Yates, John R., Da Cruz, Sandrine, Newby, Jay M., Lafarga, Miguel, Gladfelter, Amy S., Villa, Elizabeth, Cleveland, Don W.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286096/
https://ncbi.nlm.nih.gov/pubmed/33335017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abb4309
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