The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

Aggregation of TAR-DNA-binding protein 43 (TDP-43) and of its fragments TDP-25 and TDP-35 occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-43 aggregation, altering its function and exerting toxicity. Thus, inhibition of TDP-25 and TDP-35 aggregation and promotion...

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Опубликовано в: :Hum Mol Genet
Главные авторы: Crippa, Valeria, Cicardi, Maria Elena, Ramesh, Nandini, Seguin, Samuel J., Ganassi, Massimo, Bigi, Ilaria, Diacci, Chiara, Zelotti, Elena, Baratashvili, Madina, Gregory, Jenna M., Dobson, Christopher M., Cereda, Cristina, Pandey, Udai Bhan, Poletti, Angelo, Carra, Serena
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291228/
https://ncbi.nlm.nih.gov/pubmed/27466192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw232
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