The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

Lonidamine (LND) is an anti-tumour drug particularly effective at selectively sensitising tumours to chemotherapy, hyperthermia and radiotherapy, although its precise mode of action remains unclear. It has been reported to perturb the bioenergetics of cells by inhibiting glycolysis and mitochondrial...

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Detaylı Bibliyografya
Yayımlandı:Biochem J
Asıl Yazarlar: Nancolas, Bethany, Guo, Lili, Zhou, Rong, Nath, Kavindra, Nelson, David S., Leeper, Dennis B., Blair, Ian A., Glickson, Jerry D., Halestrap, Andrew P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814305/
https://ncbi.nlm.nih.gov/pubmed/26831515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151120
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