Lonidamine Induces Intracellular Tumor Acidification and ATP Depletion in Breast, Prostate and Ovarian Cancer Xenografts and Potentiates Response to Doxorubicin

We demonstrate that the effects of lonidamine (LND, 100 mg/kg, i.p.) are similar for a number of xenograft models of human cancer including DB-1 melanoma and HCC1806 breast, BT-474 breast, LNCaP prostate and A2870 ovarian carcinomas. Following treatment with LND, each of these tumors exhibits a rapi...

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Publicado en:NMR Biomed
Main Authors: Nath, Kavindra, Nelson, David S., Heitjan, Daniel F., Leeper, Dennis B., Zhou, Rong, Glickson, Jerry D.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361034/
https://ncbi.nlm.nih.gov/pubmed/25504852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3240
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