The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases

The small GTPase DiRas1 has tumor-suppressive activities, unlike the oncogenic properties more common to small GTPases such as K-Ras and RhoA. Although DiRas1 has been found to be a tumor suppressor in gliomas and esophageal squamous cell carcinomas, the mechanisms by which it inhibits malignant phe...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Bergom, Carmen, Hauser, Andrew D., Rymaszewski, Amy, Gonyo, Patrick, Prokop, Jeremy W., Jennings, Benjamin C., Lawton, Alexis J., Frei, Anne, Lorimer, Ellen L., Aguilera-Barrantes, Irene, Mackinnon, Alexander C., Noon, Kathleen, Fierke, Carol A., Williams, Carol L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813585/
https://ncbi.nlm.nih.gov/pubmed/26814130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.696831
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