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The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases

Ras family small GTPases undergo prenylation (such as farnesylation) for proper localization to the plasma membrane, where they can initiate oncogenic signaling pathways. Small GTP-binding protein GDP-dissociation stimulator (SmgGDS) proteins are chaperones that bind and traffic small GTPases, altho...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: García-Torres, Desirée, Fierke, Carol A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682747/
https://ncbi.nlm.nih.gov/pubmed/31197034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007438
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