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The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases
Ras family small GTPases undergo prenylation (such as farnesylation) for proper localization to the plasma membrane, where they can initiate oncogenic signaling pathways. Small GTP-binding protein GDP-dissociation stimulator (SmgGDS) proteins are chaperones that bind and traffic small GTPases, altho...
Gespeichert in:
| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6682747/ https://ncbi.nlm.nih.gov/pubmed/31197034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007438 |
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