Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization

Ras and Rho small GTPases possessing a C-terminal polybasic region (PBR) are vital signaling proteins whose misregulation can lead to cancer. Signaling by these proteins depends on their ability to bind guanine nucleotides and their prenylation with a geranylgeranyl or farnesyl isoprenoid moiety and...

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Hlavní autoři: Berg, Tracy J., Gastonguay, Adam J., Lorimer, Ellen L., Kuhnmuench, John R., Li, Rongshan, Fields, Alan P., Williams, Carol L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975149/
https://ncbi.nlm.nih.gov/pubmed/20709748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129916
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