The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAX Motif

Ras family small GTPases localize at the plasma membrane, where they can activate oncogenic signaling pathways. Understanding the mechanisms that promote membrane localization of GTPases will aid development of new therapies to inhibit oncogenic signaling. We previously reported that SmgGDS splice v...

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Autores principales: Schuld, Nathan J., Vervacke, Jeffrey S., Lorimer, Ellen L., Simon, Nathan C., Hauser, Andrew D., Barbieri, Joseph T., Distefano, Mark D., Williams, Carol L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945348/
https://ncbi.nlm.nih.gov/pubmed/24415755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527192
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