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Substitutions of Conserved Residues in the C-terminal Region of DnaC Cause Thermolability in Helicase Loading

The DnaB-DnaC complex binds to the unwound DNA within the Escherichia coli replication origin in the helicase loading process, but the biochemical events that lead to its stable binding are uncertain. This study characterizes the function of specific C-terminal residues of DnaC. Genetic and biochemi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Felczak, Magdalena M., Sage, Jay M., Hupert-Kocurek, Katarzyna, Aykul, Senem, Kaguni, Jon M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813501/
https://ncbi.nlm.nih.gov/pubmed/26728455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708586
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