Clinical Activity of mTOR Inhibition With Sirolimus in Malignant Perivascular Epithelioid Cell Tumors: Targeting the Pathogenic Activation of mTORC1 in Tumors

PURPOSE: Perivascular epithelioid cell tumors (PEComas) represent a family of mesenchymal neoplasms, mechanistically linked through activation of the mTOR signaling pathway. There is no known effective therapy for PEComa, and the molecular pathophysiology of aberrant mTOR signaling provided us with...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Clin Oncol
Autori principali: Wagner, Andrew J., Malinowska-Kolodziej, Izabela, Morgan, Jeffrey A., Qin, Wei, Fletcher, Christopher D.M., Vena, Natalie, Ligon, Azra H., Antonescu, Cristina R., Ramaiya, Nikhil H., Demetri, George D., Kwiatkowski, David J., Maki, Robert G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2010
Soggetti:
Original Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810029/
https://ncbi.nlm.nih.gov/pubmed/20048174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.2981
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi