Clinical Activity of mTOR Inhibition With Sirolimus in Malignant Perivascular Epithelioid Cell Tumors: Targeting the Pathogenic Activation of mTORC1 in Tumors

PURPOSE: Perivascular epithelioid cell tumors (PEComas) represent a family of mesenchymal neoplasms, mechanistically linked through activation of the mTOR signaling pathway. There is no known effective therapy for PEComa, and the molecular pathophysiology of aberrant mTOR signaling provided us with...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Wagner, Andrew J., Malinowska-Kolodziej, Izabela, Morgan, Jeffrey A., Qin, Wei, Fletcher, Christopher D.M., Vena, Natalie, Ligon, Azra H., Antonescu, Cristina R., Ramaiya, Nikhil H., Demetri, George D., Kwiatkowski, David J., Maki, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810029/
https://ncbi.nlm.nih.gov/pubmed/20048174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.2981
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados