Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis

BACKGROUND: Tuberous sclerosis (TSC) is a hamartoma syndrome in which renal and lung tumors cause the greatest morbidity. Loss of either TSC1 or TSC2 in TSC hamartomas leads to activation of mTORC1 and suppression of AKT. Recent studies indicate that inhibition of mTORC1 with RAD001 (everolimus) lea...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pollizzi, Kristen, Malinowska-Kolodziej, Izabela, Stumm, Michael, Lane, Heidi, Kwiatkowski, David
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702302/
https://ncbi.nlm.nih.gov/pubmed/19527517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-38
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados