Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis

A single cycle of strain improvement was performed in Saccharopolyspora erythraea mutB and 15 genotypes influencing erythromycin production were found. Genotypes generated by transposon mutagenesis appeared in the screen at a frequency of ∼3%. Mutations affecting central metabolism and regulatory ge...

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Detalles Bibliográficos
Publicado en:FEMS Microbiol Lett
Autores principales: Fedashchin, Andrij, Cernota, William H., Gonzalez, Melissa C., Leach, Benjamin I., Kwan, Noelle, Wesley, Roy K., Weber, J. Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Research Letter
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809991/
https://ncbi.nlm.nih.gov/pubmed/26468041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsle/fnv180
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