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Engineering of the methylmalonyl-CoA metabolite node for increased erythromycin production in oil-based fermentations of Saccharopolyspora erythraea

Engineering of the methylmalonyl-CoA (mmCoA) metabolite node of the Saccharopolyspora erythraea wild type strain (FL2267) through duplication of the mmCoA mutase (MCM) operon led to a 51% (range 40%-64%, 0.95 CI, N = 152) increase in erythromycin production in a high-performance oil-based fermentati...

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Bibliografiske detaljer
Main Authors: Reeves, Andrew R., Brikun, Igor A., Cernota, William H., Leach, Benjamin I., Gonzalez, Melissa C., Weber, J. Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722834/
https://ncbi.nlm.nih.gov/pubmed/17482861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2007.02.001
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