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Engineering of the methylmalonyl-CoA metabolite node for increased erythromycin production in oil-based fermentations of Saccharopolyspora erythraea
Engineering of the methylmalonyl-CoA (mmCoA) metabolite node of the Saccharopolyspora erythraea wild type strain (FL2267) through duplication of the mmCoA mutase (MCM) operon led to a 51% (range 40%-64%, 0.95 CI, N = 152) increase in erythromycin production in a high-performance oil-based fermentati...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722834/ https://ncbi.nlm.nih.gov/pubmed/17482861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2007.02.001 |
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