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Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors

Neuroactive steroids are efficacious modulators of γ-aminobutyric acid type A receptor (GABA(A)) receptor function. The effects of steroids on the GABA(A) receptor are typically determined by comparing steady-state single-channel open probability or macroscopic peak responses elicited by GABA in the...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Chakrabarti, Sampurna, Qian, Mingxing, Krishnan, Kathiresan, Covey, Douglas F., Mennerick, Steven, Akk, Gustav
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809306/
https://ncbi.nlm.nih.gov/pubmed/26769414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.102202
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