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Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation
Neurosteroids are potent modulators of GABA-A receptors. We have examined the time course of development of potentiation of α1β2γ2L GABA-A receptors during coapplication of GABA and an endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α5αP). The simultaneous application of 3α5αP with 5 μm GA...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276993/ https://ncbi.nlm.nih.gov/pubmed/17761771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142794 |
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