Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation

Neurosteroids are potent modulators of GABA-A receptors. We have examined the time course of development of potentiation of α1β2γ2L GABA-A receptors during coapplication of GABA and an endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α5αP). The simultaneous application of 3α5αP with 5 μm GA...

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Autors principals: Li, Ping, Shu, Hong-Jin, Wang, Cunde, Mennerick, Steven, Zorumski, Charles F, Covey, Douglas F, Steinbach, Joe Henry, Akk, Gustav
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2007
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276993/
https://ncbi.nlm.nih.gov/pubmed/17761771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142794
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