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Noncatalytic Requirement for Cyclin A-cdk2 in p27 Turnover
Ubiquitin-dependent proteolysis makes a major contribution to decreasing the levels of p27. Ubiquitin-dependent proteolysis of p27(kip1) is growth and cell cycle regulated in two ways: first, skp2, a component of the E3-ubiquitin ligase, is growth regulated, and second, a kinase must phosphorylate t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC480915/ https://ncbi.nlm.nih.gov/pubmed/15199159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.6058-6066.2004 |
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